Theoretical background a) Principles of lanthanide luminescence mechanisms: Excitation and emission mechanisms b) Term symbols and group theoretical aspects c) Nonlinear optical processes: two-photon excitation in lanthanide complexes d) Up- and down conversion e) Luminescent lanthanide-doped molecules and nanoparticles    
Academic research and technological aspects a) Luminescent nanoparticles and nanocomposites b) Luminescent lanthanide and magnetic materials for medical diagnostics c) FRET in lanthanide-based luminescent immunoassays d) Nanoparticles surface modification with lanthanide complexes e) NIR lanthanide materials for bioimaging f) Intracellular FRET-based probes g) Multimodal imaging
Applications a) Bioimaging b) Optical markers and sensors c) Industrial developments and perspectives d) Instrumentation and novel diagnostic techniques for systems and devices e) Industrial development and perspectives f) Luminescent lanthanide complexes in cancer diagnostics and therapy

Tentative list of lecture titles


Prof. Stephane Petoud, Center for Molecular Biophysics in Orléans, France

1. Near-infrared emitting probes for biological imaging : Organic fluorophores, quantum dots, fluorescent proteins, lanthanide(III)complexes and nanomaterials

2. Luminescence of Lanthanide cations for bioanalytical application and optical imaging: history and perspectives

3. Multimodal lanthanide based imaging agents

Dr Loïc J. Charbonnière, Institut Pluridisciplinaire Hubert Curien (IPHC), Strasbourg, France

1. up and down conversion : "molecular up conversion, basics and examples"

2. Nanoparticle surface modification with lanthanide complex : "Surface ligands for improved brightness of luminescent lanthanide doped nanoparticles"

Prof. Stefan Lis, Adam Mickiewicz University, Poznan, Poland

1. Photoluminescence of lanthanide ions, Ln3+, in systems with organic and inorganic ligands, factors affecting their luminescence effectiveness.

2. Advantages of changes of the size from bulk materials to nanoparticles, NPs. Synthesis strategy and characterization methods of nanoluminophores and up-converting emitters based on inorganic matrices doped with Ln3+.

3. Nanomaterials containing rare earths ions: core-shell and surface functionalized NPs, multifunctional hybrids, and their applications.

Dr. Svetlana Eliseeva, Centre de Biophysique Moléculaire – CNRS, Orléans, France

“Photophysical properties and optical imaging applications of lanthanide-based metallacrowns”

Dr. Olivier Sénèque, Laboratoire de Chimie et Biologie des Métaux, CEA, Grenoble, France

1. Design strategies in lanthanide-based responsive probes.

2. Lanthanide-protein or peptide conjugates for biological applications: synthesis and applications.

Prof. Niko  Hildebrandt, Institut de Biologie Intégrative de la Cellule, Paris, France

1. FRET – Förster Resonance Energy Transfer (History, Theory, and Application)

2. Time-gated FRET Bionsensing using Lanthanide Donors

3. Terbium-to-Quantum Dot FRET for Multiplexed Biosensors

Prof. Cees Ronda, Philips, The Nethertlands

1. Introduction to group theory

2. Luminescence mechanisms

3. Applications of luminescence

Dr Jurriaan Zwier, Cisbio Bioassays, Codolet, France

1. Homogeneous Time Resolved Fluorescence (HTRF®) assays: recent applications for the life sciences.

2. TR-FRET sensors using Eu3+ and Tb3+ complexes to study cell surface receptors on living cells.

Prof. Éva Jakab Tóth, Center for Molecular Biophysics in Orléans, France

1. to be given soon

2. to be given soon

Prof. Eszter Borbas, Ångström laboratory, Uppsala, Sweden

1. to be given soon

2. to be given soon

Prof. Luís Dias Carlos, University of Aveiro, Aveiro, Portugal

1. Luminescence thermometry: A new tool in biomedicine

2. Where now for luminescence thermometry?

Dr Valentina Utochnikova, Lomonosov Moscow State University, Moscow, Russia

1. to be given soon

2. to be given soon

Dr Daniel Jaque, Universidad Autónoma de Madrid, Madrid, Spain

1. Part 1: Infrared nanoparticles for imaging, diagnosis and therapy

2. Part 2: Infrared nanoparticles for imaging, diagnosis and therapy